Anticonvulsant Effects of New 1, 4-Dihydropyridine Derivatives Containing Imidazolyl Moiety Against Seizures Induced by Pentylenetetrazole and Maximal Electroshock in Mice

Epilepsy is a chronic disorder of the brain affecting around 50 million people in the world.Up to 30% of epileptic patients do not respond to available drugs and medical therapies. In thispaper, anticonvulsant screening of 10 synthesized new derivatives of 1, 4-dihydropyridine-3,5-dicarboxamides was performed.Anticonvulsant activity was evaluated by intravenous and intraperitoneal pentylenetetrazoleand maximal electroshock induced seizures tests. Nifedipine was used as reference drug. Ourpharmacological results revealing the compounds 2, 4, 5, and 6 can be effective in both absenceand grandmal seizures in human.These pharmacological studies have displayed that these new dihydropyridine derivativesare capable to inhibiting seizures induced by pentylenetetrazole and maximal electroshock inmice efficiently.